Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants was written by Robertson, Linsey;Hartley, Richard C.. And the article was included in Tetrahedron in 2009.COA of Formula: C11H17N This article mentions the following:
The generation of excess reactive oxygen species (ROS) in mitochondria is responsible for much of the oxidative stress associated with aging, and mitochondrial dysfunction is part of the pathol. of neurodegeneration and type 2 diabetes. Lipophilic pyridinium ions are known to accumulate in mitochondria and this paper describes a general route for the preparation of nitrone-containing N-arylpyridinium salts having a range of lipophilicities, as potential therapeutic antioxidants. The compatibility of nitrones with the Zincke reaction is the key to their synthesis. Their trapping of carbon-centered radicals and the EPR spectra of the resulting nitroxides are reported. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0COA of Formula: C11H17N).
4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. COA of Formula: C11H17N