On August 30, 2018, Robke, Lucas; Rodrigues, Tiago; Schroeder, Peter; Foley, Daniel J.; Bernardes, Goncalo J. L.; Laraia, Luca; Waldmann, Herbert published an article.Name: 3,5-Dibromo-4-methoxypyridine The title of the article was Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors. And the article contained the following:
Autophagy is a catabolic process, which mediates degradation of cellular components and has important roles in health and disease. Therefore, small mol. modulators of autophagy are in great demand. Herein, we describe a phenotypic high-content screen for autophagy inhibitors, which led to the discovery of a dimethoxypyridine-based class of autophagy inhibitors, which derive from previously reported, natural product-inspired MAP4K4 inhibitors. Comprehensive structure-activity relationship studies led to a potent compound, and biol. validation experiments indicated that the mode of action was upstream or independent of mTOR. The experimental process involved the reaction of 3,5-Dibromo-4-methoxypyridine(cas: 25813-24-5).Name: 3,5-Dibromo-4-methoxypyridine
The Article related to dimethoxy pyridine derivative preparation autophagy inhibitor structure, Pharmacology: Structure-Activity and other aspects.Name: 3,5-Dibromo-4-methoxypyridine