Ring transformations in reactions of heterocyclic halo compounds with nucleophiles. XII. Action of potassium amide on 2-bromo-and 2,6-dibromo-3-hydroxypyridine was written by Roelfsema, W. A.;Den Hertog, H. J.. And the article was included in Tetrahedron Letters in 1967.Product Details of 6602-33-1 This article mentions the following:
2-Bromo-3-hydroxypyridine (I) was prepared from 3-ethoxy-2-nitropyridine. I treated 2 hrs. at -33° with an 8-fold molar amount of KNH2 in liquid NH3 yielded 85% pyrrole-2-carboxamide (II), m. 172.5-4.0°, also synthesized from pyrrole-2-carboxylic acid. Similarly 2,6-dibromo-3-hydroxypyridine, prepared from 3-hydroxypyridine, was converted to 80% 5-bromopyrrole-2-carboxamide, m. 136-8°. Apparently the conversion occurs without bond fission between C-2 and C-3 as in the analogous transformations of 3-amino-2-bromopyridine and 3-amino-2-bromoquinoline, but that the pyridine rings are broken between C-3 and C-4 atoms. A tentative reaction scheme for the conversion is given. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Product Details of 6602-33-1).
2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 6602-33-1