Aryl H-phosphonates. 19. New anti-HIV pro-nucleotide phosphoramidate diesters containing amino- and hydroxypyridine auxiliaries was written by Romanowska, Joanna;Kolodziej, Krystian;Sobkowski, Michal;Rachwalak, Marta;Jakubowski, Tomasz;Golebiewska, Justyna;Kraszewski, Adam;Boryski, Jerzy;Dabrowska, Aleksandra;Stawinski, Jacek. And the article was included in European Journal of Medicinal Chemistry in 2019.Application of 626-64-2 This article mentions the following:
We have designed a new type of AZT and ddU phosphoramidate diesters containing various combinations of 2-, 3-, 4-aminopyridine and 2-, 3-, 4-hydroxypyridine moieties attached to the phosphorus center, as potential anti-HIV pro-nucleotides. Depending on the pKa values of the aminopyridines and the hydroxypyridines used, alternative synthetic strategies based on H-phosphonate chem. were developed for their preparation Synthetic aspects of these transformations and the biol. activity of the synthesized compounds are discussed. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application of 626-64-2).
Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 626-64-2