Ross, John H. published the artcileStructure-activity correlations of amines inhibiting active uptake of paraquat (methyl viologen) into rat lung slices, Formula: C26H42Br2N2, the main research area is paraquat uptake lung amine.
Anal. of amine structure with respect to inhibitory potency utilized a new method for determining equipotent inhibitor concentrations of paraquat dichloride (I dichloride) [1910-42-5] uptake by lung slices. Fifteen N-alkyl homologs of I (viologens) were tested and inhibition of lung uptake of I was a function of the inductive effect and steric bulk of groups attached to the nitrogens of 4,4′-bipyridyl. Several classes of amine inhibitors were examined Polyamines were generally more potent than compounds containing only 1 quaternizable N at pH 7.4. α,ω-Diaminoalkanes were the most potent inhibitors of I accumulation by lung slices.
Toxicology and Applied Pharmacology published new progress about Lung. 36437-30-6 belongs to class pyridine-derivatives, name is 1,1-Di-n-octyl-4,4-bipyridinium Dibromide, and the molecular formula is C26H42Br2N2, Formula: C26H42Br2N2.