《Hydrogen-bond-driven thiouracil dissolution in aqueous ionic liquid: A combined microscopic, spectroscopic and molecular dynamics study》 was written by Sahoo, Dipak Kumar; Chand, Apramita; Jena, Subhrakant; Biswal, Himansu S.. Application In Synthesis of Picolinic acidThis research focused onthiouracil choline picolinate hydrogen bond solubility. The article conveys some information:
Ionic liquids (ILs) over the years, have been maneuvered in aiding the dissolution of poorly soluble drugs, boosting their permeation and delivery to the target areas through the physiol. barrier. Herein, the solubility of a simple anti-carcinogenic and anti-thyroid drug 2-thiouracil (TU), with poor solubility in water as well as common organic solvents was explored by employing a biocompatible IL – Choline picolinate ([Ch][Pic]). With field-emission scanning-electron-microscope, NMR and mol.-dynamics (MD) simulation studies, we unleashed the solubility mechanism and dynamics of TU in water and in aqueous IL solution The solubility of TU in the IL was enhanced by 100 times than that of water. Electron microscopy showed time-dependent nano- and microscale self-organization morphol. during the solvation process. NMR and MD simulation revealed a tug of war between TU and water to interact with IL, and hydrogen bonding is the prominent interaction for the enhanced solubility The present results are encouraging and can be extended to other thio-derivatives of nucleobases that are useful for biochem. and pharmaceutical applications. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid)
Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application In Synthesis of Picolinic acid