Recommanded Product: 3510-66-5In 2019 ,《A greener approach toward N-1 heteroarylation of indoles: Synthesis and in vitro evaluation of potential anti-proliferative agents》 appeared in Arabian Journal of Chemistry. The author of the article were Sailaja, E.; Bhavani, S.; Rambabu, D.; Basaveswara Rao, M. V.; Pal, Manojit. The article conveys some information:
A greener approach was developed to synthesize N-pyridyl indoles e.g., I [R1 = R2 = H, R3 = 2-pyridyl] and N-pyrimidinyl indoles e.g., I [R1 = R2 = H, R3 = 2-pyrimidinyl] via an ultrasound assisted selective N-1 heteroarylation of indoles. This methodol. involved reaction of indoles with heteroaryl halides in PEG-400 under ultrasound irradiation Compound I [R1 = R2 = H, R3 = 2-pyrimidinyl] was benzoylated at C-2 position via palladium-mediated C-H bond activation. All the synthesized N-1 heteroarylindoles were tested for their in vitro anti-proliferative properties against cancer (leukemia) and non-cancerous cell lines. Among the tested compounds, compounds I [R1 = H; R2 = 5-OMe; R3 = 2-pyridyl, 5-Me-2-pyridyl, 2-pyrimidinyl] showed promising activity against K562 leukemia cells whereas compound I [R1 = H, R2 = 5-OMe, R3 = 2-pyrimidinyl] showed significant activity against Colo-205 cells. Addnl., none of these N-heteroaryl indoles showed any effect against noncancerous HEK293 cell lines, indicating their selectivity toward cancer cells specifically leukemia. In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5) was used in this study.
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 3510-66-5