Sakai, Hiroki published the artcileSecond basic pKa: An overlooked parameter in predicting phospholipidosis-inducing potential of diamines, Quality Control of 149489-32-7, the main research area is phospholipidosis pos diamine second basic pKa PLIP; Diamine; Phospholipidosis; Second basic pKa.
In this paper, we present the phospholipidosis-inducing potential (PLIP) of forty fragment-sized diamines derived from N-benzyl-4-(methylamino)piperidine and discuss the relationship between their PLIP and the physicochem. properties. Our results demonstrate that the previously reported methods are not suitable for predicting the PLIP of fragment-sized diamines; the second basic pKa can distinguish PLIP-pos. diamines from PLIP-neg. diamines more accurately than ClogP or most basic pKa. To the best of our knowledge, this is the first report describing the relationship between PLIP and second basic pKa.
Bioorganic & Medicinal Chemistry Letters published new progress about Chemical potential (phospholipidosis-inducing potential (PLIP)). 149489-32-7 belongs to class pyridine-derivatives, name is 2-(Chloromethyl)-3-fluoropyridine, and the molecular formula is C6H5ClFN, Quality Control of 149489-32-7.