Salameh, Nihad published the artcileHeterogeneous palladium-catalysed intramolecular C(sp3)-H α-arylation for the green synthesis of oxindoles, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Molecular Catalysis (2022), 112211, database is CAplus.
The development of a waste-minimized protocol for the synthesis of oxindoles I [R = H, Me; R1 = Me, Et, Bn; R2 = H, Me, F; R3 = H, F, Me, CF2; R4 = H, Me, Cl, CN, etc.; R5 = CH, N] using cyclopentyl Me ether (CPME) as a safe and green reaction medium and palladium on carbon (Pd/C) as a reusable catalyst was presented. This protocol is efficiently applied to a variety of substrates 2-R2-3-R3-4-R4-5-R5-6-X-C6N(R1)C(O)CH3 [X = Br, Cl] affording products I with excellent yields, minimal metal contamination and min. waste production The catalyst was recovered and reused for four consecutive runs without any apparent loss of efficiency. Moreover, products I were isolated by simple precipitation from heptane with no need for chromatog. separations, and both CPME and heptane were recovered. Waste-minimization is reflected by the low E-factor calculated for the presented protocol.
Molecular Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem