In 2012,Salvi, Luca; Davis, Nicole R.; Ali, Siraj Z.; Buchwald, Stephen L. published 《A New Biarylphosphine Ligand for the Pd-Catalyzed Synthesis of Diaryl Ethers under Mild Conditions》.Organic Letters published the findings.HPLC of Formula: 13534-97-9 The information in the text is summarized as follows:
A new bulky biarylphosphine ligand has been developed that allows the Pd-catalyzed C-O cross-coupling of a wide range of aryl halides and phenols under milder conditions. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9HPLC of Formula: 13534-97-9)
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.HPLC of Formula: 13534-97-9