Sanchez Delgado, Giset Y.; Ferreira, Frederico Henrique do C.; Paschoal, Diego F. S.; Dos Santos, Helio F. published the artcile< The role of tridentate ligands on the redox stability of anticancer gold(III) complexes>, Reference of 366-18-7, the main research area is Chelating effect; DFT; Gold(III) complexes; Redox stability; VT-HAA; VT-HXAA.
Gold(III) complexes are promising compounds for cancer chemotherapy, whose action depends on their redox stability. In this context, the choice of ligands is crucial to adjust their reactivity and biol. response. The present study addressed the effect of the gold coordination sphere on the reduction potential (Eo) for ten gold(III) complexes containing five or six-membered rings tridentate ligands – [AuIII(trident)Cl]3+n (trident = NN̂N̂, CN̂N̂, CĈN̂, CN̂Ĉ, and NĈN̂). The calculated Eo covered a broad range of 2500 mV with the most stable complexes containing two Au-C bonds (Eo = -1.85 V for [AuIII(CĈN̂)Cl] – f). For complexes with one Au-C bond, the NĈN̂ ligands stabilize the gold(III) complex more efficiently than NN̂Ĉ; however, the inclusion of the non-innocent ligand bipy (2,2′-bipyridine) in NN̂ portion provides an extra stabilization effect. Among the derivatives with one Au-C bond, [AuIII(NN̂Ĉ)Cl]+ (NN̂ = bipy) (a) showed Eo = -1.20 V. For the complexes with NN̂N̂ ligands, Eo was pos. and almost constant (+0.60 V). Furthermore, the kinetics for ligand exchange reactions (Cl-/H2O, H2O/Cys and Cl-/Cys) were monitored for the most stable compounds and the energy profiles compared to the reduction pathways.
Journal of Inorganic Biochemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Reference of 366-18-7.