Sarpal, Kanika published the artcileAmorphous Solid Dispersions of Felodipine and Nifedipine with Soluplus: Drug-Polymer Miscibility and Intermolecular Interactions, Application In Synthesis of 21829-25-4, the main research area is felodipine nifedipine soluplus miscibility polymer; Amorphous solid dispersions; Hydrogen bonding; Phase heterogeneity; Solid-state nuclear magnetic resonance spectroscopy; Thermodynamic miscibility.
The objective of this study was to investigate thermodn. and kinetic miscibility for two structurally similar model compounds nifedipine (NIF) and felodipine (FEL) when formulated as amorphous solid dispersions (ASDs) with an amphiphilic polymer Soluplus. Thermodn. miscibility was studied via m.p. depression approach for the two systems. The Flory Huggins theory was used to calculate the interaction parameter and generate the phase diagrams. It was shown that NIF was more miscible in Soluplus than FEL. The nature of drug-polymer interactions was studied by fourier transform infra-red spectroscopy (FTIR) and solid-state NMR spectroscopy (ssNMR). The data from spectroscopic analyses showed that both the drugs interacted with Soluplus through hydrogen bonding interactions. Furthermore, 13C ssNMR data was used to get quant. estimate of the extent of hydrogen bonding for ASDs samples. Proton relaxation measurements were carried out on ASDs in order to evaluate phase heterogeneity on two different length scales of mixing. The data suggested that better phase homogeneity in NIF:SOL systems especially for lower Soluplus content ASDs on smaller domains. This could be explained by understanding the extent of hydrogen bonding interactions for these two systems. This study highlights the need to consider thermodn. and kinetic mixing, when formulating ASDs with the goal of understanding phase mixing between drug and polymer.
Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Amorphous materials. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Application In Synthesis of 21829-25-4.