Copper-Mediated Selective Mono- and Sequential Organochalcogenation of C-H Bonds: Synthesis of Hybrid Unsymmetrical Aryl Ferrocene Chalcogenides was written by Sattar, Moh.;Patidar, Krishna;Thorat, Raviraj Ananda;Kumar, Sangit. And the article was included in Journal of Organic Chemistry in 2019.Quality Control of Pyridin-4-ol This article mentions the following:
A 8-aminoquinoline directed Cu/1,10-phenanthroline-mediated selective mono-organothiolation of C-H bond in ferroceneamide was developed using aryl/alkyl-disulfide substrates. The sequential ferrocene C-H organochalcogenation (chalcogen = S, Se, and Te) also was established for the synthesis of novel hybrid unsym. aryl chalcogenides with the aid of a catalytic amount of Cu(OAc)2 under ambient reaction conditions. The developed protocol exhibits a broad functional group tolerance to allow alkyl, aryl, hetero-aryl, bromo, chloro, and nitro containing diorgano dichalcogenides as a coupling partner. Further, the 8-aminoquinoline directing group is easily removed to afford the aldehyde functionality after C-H organochalcogenation. A mechanistic understanding of the Cu-mediated selective mono-organothiolation reaction suggests that rigid bi-coordinated 1,10-phenanthroline ligand and freshly generated Cu(II) from Cu(I) in the less polar solvent MeCN seem crucial for the selective mono-C-H functionalization of ferroceneamide. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Quality Control of Pyridin-4-ol).
Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of Pyridin-4-ol