Sayed, Ahmed M. published the artcileArylpyrazole as selective anti-enterococci; synthesis and biological evaluation of novel derivatives for their antimicrobial efficacy, HPLC of Formula: 197958-29-5, the publication is Journal of Heterocyclic Chemistry, database is CAplus.
Condensation of the 1-(1-[4-substituted aryl]phenyl-5-methyl-1H-pyrazol-4-yl)ethan-1-ones with the aminoguanidinehydrochloride gave target compounds 2-(1-(1-(4-[aryl or alkyl] phenyl)-5-methyl-1Hpyrazol-4-yl)ethylidene)hydrazine-1-carboximidamides I [R = Ph, Bn, 4-MeC6H4, etc.]. Exploring the structure-activity relationships (SAR) of a new set of phenylpyrazoles I [R = Ph, Bn, 4-MeC6H4, etc.] unveiled a potential anti-enterococcus lead compound I [R = benzofuran-2-yl]. The benzofuran moiety linked to the phenylpyrazole I [R = benzofuran-2-yl] was 32 times better than vancomycin against Enterococcus fecalis ATCC 51299. Besides, compound I [R = benzofuran-2-yl] is expected to have an excellent oral bioavailability according to the in silico studies. In SAR anal., it was found that the benzofuran side chain was essential for the activity. Changing the benzofuran with either benzothiophene, Ph, pyridinyl, tolyl, or naphthyl reduces/nullifies the pharmacol. action. Besides the anti-enterococcal activity, derivatives I [R = furan-2-yl, Ph] could be used to develop new broad-spectrum antibiotics as they exhibited activity against the wild-type highly virulent Escherichia coli isolate. Moreover, compound I [R = benzothiophen-2-yl] was proved to show antifungal activity (MIC = 4 μg/mL) against the Candida albicans SS5314 (wild type).
Journal of Heterocyclic Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, HPLC of Formula: 197958-29-5.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem