Schmidt, Michael A. published the artcileEffect of Terminal Alkylation of Aryl and Heteroaryl Hydrazines in the Fischer Indole Synthesis, Computed Properties of 3469-63-4, the main research area is Fischer indole synthesis; hydrazine ketone alkylation amidation cross coupling.
The effect of alkylation on the terminal position of aryl and heteroaryl hydrazines in the Fischer indole synthesis was examined Compared to their unalkylated counterparts, reactions using alkylated s provided indole products with higher yields and faster rates. The reactions can be conducted at lower temperatures and are compatible with acid-sensitive functionality. The terminally alkylated hydrazines were readily prepared by a new two-step sequence and held as stable hydrazinium salts. The mild formation of the salts along with the favorable Fischer indole reaction conditions highlights the potential of this approach in later-stage synthetic use.
Journal of Organic Chemistry published new progress about Alkylation. 3469-63-4 belongs to class pyridine-derivatives, name is Ethyl 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylate, and the molecular formula is C11H12N2O3, Computed Properties of 3469-63-4.