《Palladium-Catalyzed C-H Alkynylation of Unactivated Alkenes》 was written by Schreib, Benedikt S.; Fadel, Marlene; Carreira, Erick M.. Name: Picolinic acid And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:
Palladium-catalyzed regio- and diastereoselective C-H functionalization with bromoalkynes and electronically unbiased olefins is reported. The picolinamide directing group enables the formation of putative 5 and 6-exo-metallacycles as intermediates to afford monoalkynylated products in up to 91% yield in a stereospecific fashion. The systematic study reveals that substrates with a wide range of substituents on the olefin and bromoalkyne coupling partners are tolerated. Chemoselective transformations were demonstrated for the obtained amides, olefins, and alkynes. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Name: Picolinic acid)
Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Name: Picolinic acid