On June 5, 2014, Scobie, Martin; Helleday, Thomas; Koolmeister, Tobias; Jacques, Sylvain; Desroses, Matthieu; Jacques-Cordonnier, Marie-Caroline published a patent.SDS of cas: 199522-66-2 The title of the patent was Preparation of pyrimidine-2,4-diamine derivatives for treatment of cancer. And the patent contained the following:
A compound of formula I, or a pharmaceutically acceptable salt thereof, is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1. Compounds of formula I wherein R1 is (un)substituted heteroaryl and (un)substituted aryl; R2 is H, halo, CN, (un)substituted C1-12 alkyl, etc.; R3 is (un)substituted C1-12 alkyl and (un)substituted heterocycloalkyl; R2R3 can be taken together to form 5- to 8-membered nonaromatic ring; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by amination of 4-chloro-6-phenylpyrimidin-2-amine with cyclohexanamine. The invention compounds were evaluated for their MTH1 inhibitory activity (data given). The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).SDS of cas: 199522-66-2
The Article related to pyrimidinediamine preparation treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 199522-66-2