In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. For this reason, pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Category: pyridine-derivatives.
Scott, James S.;Moss, Thomas A.;Barlaam, Bernard;Davey, Paul R. J.;Fairley, Gary;Gangl, Eric T.;Greenwood, Ryan D. R.;Hatoum-Mokdad, Holia;Lister, Andrew S.;Longmire, David;Polanski, Radoslaw;Stokes, Stephen;Tucker, Michael J.;Varnes, Jeffrey G.;Yang, Bin research published 《 Addition of Fluorine and a Late-Stage Functionalization (LSF) of the Oral SERD AZD9833》, the research content is summarized as follows. Herein we describe our efforts using a late stage functionalization together with more traditional synthetic approaches to generate fluorinated analogs of the clin. candidate AZD9833. The effects of the addition of fluorine on the lipophilicity, permeability, and metabolism are discussed. Many of these changes were tolerated in terms of pharmacol. and resulted in high quality mols. which reached advanced stages of profiling in the testing cascade.
31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.
5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., Category: pyridine-derivatives