COA of Formula: C6H5NO. Recently I am researching about QUORUM-SENSING SYSTEMS; PLATE-BASED ASSAY; SIGNAL; VIRULENCE; MOTILITY; CELL; LAS; PATHOGENESIS; DISCOVERY; TARGETS, Saw an article supported by the International Centre for Genetic Engineering and Biotechnology, Italy [CRP16-02]; Ministry of Education, Science and Technological Development, Republic of Serbia [173048, 172008]; FP7 RegPot project FCUB ERA GA [256716]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Aleksic, I; Jeremic, J; Milivojevic, D; Ilic-Tomic, T; Segan, S; Zlatovic, M; Opsenica, DM; Senerovic, L. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde
Pseudomonas aeruginosa is a leading cause of nosocomial infections that are becoming increasingly difficult to treat due to the occurrence of antibiotic resistant strains. Since P. aeruginosa virulence is controlled through quorum sensing, small molecule treatments inhibiting quorum sensing signaling pathways provide a promising therapeutic option. Consequently, we synthesized a series of N-octaneamino-4-aminoquinoline derivatives to optimize this chemotype’s antivirulence activity against P. aeruginosa via inhibition of pyocyanin production. The most potent derivative, which possesses a benzofuran substituent, provided effective inhibition of pyocyanin production (IC50 = 12 mu M), biofilm formation (BFIC50 = 50 mu M), and motility. Experimentally, the compound’s activity is achieved through competitive inhibition of PqsR, and structure-activity data were rationalized using molecular docking studies.
COA of Formula: C6H5NO. Welcome to talk about 500-22-1, If you have any questions, you can contact Aleksic, I; Jeremic, J; Milivojevic, D; Ilic-Tomic, T; Segan, S; Zlatovic, M; Opsenica, DM; Senerovic, L or send Email.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem