Recently I am researching about BIOLOGICAL EVALUATION; ISOZYMES I; ISOFORMS I; DRUG DESIGN; HYDRAZONE; POTENT; COMPLEXES; XII; SOLUBILITY; ANALOGS, Saw an article supported by the Anadolu University Scientific Projects Fund [1803S050]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Saglik, BN; Cevik, UA; Osmaniye, D; Levent, S; Cavusoglu, BK; Demir, Y; Ilgin, S; Ozkay, Y; Koparal, AS; Beydemir, S; Kaplancikli, ZA. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. Product Details of 500-22-1
New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles of the synthesized compounds on hCA I-II isoenzyme were investigated by comparing their IC50 and K-i values. Acetazolamide (5-acetamido-1,3,4-thia-diazole-2-sulfonamide, AZA) has also been used as a standard inhibitor. The compound 3e demonstrated the best hCA I inhibitory effect with a K-i value of 0.1676 +/- 0.017 mu M. Besides, the compound 3m showed the best hCA II inhibitory effect with a K-i value of 0.2880 +/- 0.080 mu M. Cytotoxicity of the compounds 3e and 3m toward NIH/3T3 mouse embryonic fibroblast cell line was observed and the compounds were found to be non-cytotoxic. Molecular docking studies were performed to investigate the interaction types between active compounds and hCA enzymes. Pharmacokinetic profiles of compounds were assessed by theoretical ADME predictions. As a result of this study a novel and potent class of CA inhibitors were identified with a good activity potential.
Product Details of 500-22-1. Welcome to talk about 500-22-1, If you have any questions, you can contact Saglik, BN; Cevik, UA; Osmaniye, D; Levent, S; Cavusoglu, BK; Demir, Y; Ilgin, S; Ozkay, Y; Koparal, AS; Beydemir, S; Kaplancikli, ZA or send Email.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem