Recommanded Product: Phenyl(pyridin-2-yl)methanone. I found the field of Science & Technology – Other Topics very interesting. Saw the article Photoredox-Catalyzed Enantioselective alpha-Deuteration of Azaarenes with D2O published in 2019.0, Reprint Addresses Qiao, BK; Jiang, ZY (corresponding author), Henan Univ, Key Lab Nat Med & Immunoengn Henan Prov, Kaifeng 475004, Henan, Peoples R China.; Jiang, ZY (corresponding author), Henan Normal Univ, Henan Key Lab Organ Funct Mol & Drug Innovat, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.
The site-specific incorporation of deuterium (D) into small molecules is frequently used to access isotopically labeled compounds with broad utility in many research areas, such as drug development, mechanistic studies, and NMR analyses. Nevertheless, the deuteration of a stereocenter in an enantioselective manner, which could slow the metabolism and improve the bioavailability of bioactive molecules, remains challenging owing to the lack of established catalytic methods. Here, we report an asymmetric alpha-deuteration strategy for azaarenes with inexpensive D2O as the deuterium source. A cooperative visible light-driven photoredox and chiral Bronsted acid-catalyzed system using a Hantzsch ester as the terminal reductant has been developed, which enables racemic alpha-chloro-azaarenes and prochiral azaarene-substituted ketones to experience a single-electron reduction-enantioselective deuteration process. The transition metal-free method provides important chiral alpha-deuterated azaarenes in satisfactory yields with good to excellent enantioselectivities (up to 99% ee) and substantial deuterium incorporation.
Welcome to talk about 91-02-1, If you have any questions, you can contact Shao, TJ; Li, YJ; Ma, NN; Li, CY; Chai, GB; Zhao, XW; Qiao, BK; Jiang, ZY or send Email.. Recommanded Product: Phenyl(pyridin-2-yl)methanone
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem