Scalable C-H Oxidation with Copper: Synthesis of Polyoxypregnanes was written by See, Yi Yang;Herrmann, Aaron T.;Aihara, Yoshinori;Baran, Phil S.. And the article was included in Journal of the American Chemical Society in 2015.Electric Literature of C7H6N2 This article mentions the following:
Steroids bearing C12 oxidations are widespread in nature, yet only one preparative chem. method addresses this challenge in a low-yielding and not fully understood fashion: Schoenecker’s Cu-mediated oxidation This work shines new light onto this powerful C-H oxidation method through mechanistic investigation, optimization, and wider application. Culminating in a scalable, rapid, high-yielding, and operationally simple protocol, this procedure is applied to the first synthesis of several parent polyoxypregnane natural products, representing a gateway to over 100 family members. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Electric Literature of C7H6N2).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Electric Literature of C7H6N2