Supersonic jet studies of alkyl-substituted pyrazines and pyridines. Minimum-energy conformations and torsional motion was written by Seeman, Jeffrey I.;Paine, John B. III;Secor, Henry V.;Im, Hoong Sun;Bernstein, E. R.. And the article was included in Journal of the American Chemical Society in 1992.Product Details of 644-98-4 This article mentions the following:
Conformational preference for methyl-, ethyl-, propyl-, and isopropyl-substituted pyrazines and pyridines are determined by mass resolved excitation spectroscopy (MRES) and MOPAC 5/PM3 semiempirical calculations The results suggest that the conformational behavior of alkyl-substituted pyrazines and pyridines is different from that of alkyl-substituted benzenes. Based on the exptl. and semiempirical theor. results reported herein and published ab initio calculations, this difference can be attributed to a stabilizing interaction between an α-hydrogen atom of the alkyl substituent and the adjacent lone pair nonbonding electrons on the ring nitrogen atom. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Product Details of 644-98-4).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Product Details of 644-98-4