Electric Literature of 77992-44-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 77992-44-0, name is (5-Bromopyridin-2-yl)hydrazine. A new synthetic method of this compound is introduced below.
A mixture of 369 mg (1.3 mmol) of the compound from Example 44A, 250 mg (1.3 mmol) of the compound from Example 10A and 46 mg (0.3 mmol) p-toluenesulfonic acid in 5 ml THF is reacted in a single mode microwave (Emrys Optimizer) at 170 C. for 30 min. After addition of 2 ml formic acid to the reaction solution, the solid which has precipitated out is filtered off, stirred with 3 ml of a 4 N solution of hydrogen chloride in dioxane, filtered off again, washed first with acetonitrile and then with diethyl ether and dried in vacuo.Yield: 163 mg (30% of th.)LC-MS (Method 10): Rt=1.06 min; MS (ESIpos): m/z=374 [M+H]+;1H-NMR (400 MHz, DMSO-d6): delta=8.65 (s, 1H), 8.45 (s, 1H), 8.38-8.23 (m, 2H), 8.19 (s, 1H), 8.15 (s, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,77992-44-0, (5-Bromopyridin-2-yl)hydrazine, and friends who are interested can also refer to it.
Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2010/305085; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem