Synthetic Route of 800401-68-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 800401-68-7, name is 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid, molecular formula is C8H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a stirred solution of 10a-d (2.3 mmol) in anhydrous THF (20 mL) dimethylaminopyridine(DMAP, 2.3 mmol) was added, followed by EDCI (1.2 mmol) after 10 min; the reaction mixture wasstirred at room temperature for 1h. The suitable acid 10a-d (1.0 mmol) and EDCI (1.2 mmol) wereadded and the reaction mixture was stirred for 48 h. The solid was collected by filtration, purified byflash chromatography using CH2Cl2/MeOH 98:2 and recrystallized from CH2Cl2 and MeOH, affordingthe desired product as a yellow solid. Compounds 5a-e were characterized only by 1H-NMR spectroscopy.The poor solubility of the title compounds prevented 13C-NMR spectra from being recorded.
According to the analysis of related databases, 800401-68-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Parrino, Barbara; Span, Virginia; Carbone, Anna; Barraja, Paola; Diana, Patrizia; Cirrincione, Girolamo; Montalbano, Alessandra; Molecules; vol. 19; 9; (2014); p. 13342 – 13357;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem