Adding a certain compound to certain chemical reactions, such as: 13534-98-0, 4-Amino-3-bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 13534-98-0, blongs to pyridine-derivatives compound. Product Details of 13534-98-0
In a flask, 346 mg (2 mmol) of 3-bromo-4-aminopyridine, 303 mg (3 mmol) of triethylamine, 13 mg (0.1 mmol) of DMAP, 20 ml of dry dichloromethane, and cooled to 0 C,Add 670 mg (2.4 mmol) of triphenylchloromethane, react at room temperature, and monitor by TLC.After completion of the reaction, 30 ml of water was added, and the mixture was extracted three times with 30 mL of ethyl acetate. In a three-necked flask equipped with a reflux condenser and a constant pressure dropping funnel, magnesium chips (58 mg, 2.4 mmol) and a catalyst amount of iodine particles were added, and the surface of the magnesium chips was heated to a magenta color, and then a small amount of tetrahydrofuran was added to cover the magnesium particles. .3-bromo-4-(trityloxy)pyridine (622 mg, 1.5 mmol) obtained in the above step was dissolved in 5 ml of tetrahydrofuran, and added dropwise to a three-necked flask. The electric heating gun was slightly heated to initiate the reaction, and then slowly. Drip the remaining solution.After the dropwise addition, the reaction flask was kept at 40 C for 2 hours. Return to room temperature and let stand. To a 100 mL one-necked flask, 267 mg (1.5 mmol) of 1,4-dicyanophthalene and 20 mL of tetrahydrofuran were added, and the mixture was cooled to 0 C, and the reagent of the above format was slowly added dropwise to the reaction system, followed by room temperature.After the reaction was monitored by thin layer chromatography, the reaction was quenched with 1M HCl.Extracted three times with 30 mL of ethyl acetate, combined ethyl acetate and concentrated.Over the fast column to obtain the target compound501 mg, yield 49%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13534-98-0, its application will become more common.
Reference:
Patent; Southern Medical University; Zhang Jiajie; Tian Yuanxin; Pang Jianxin; (37 pag.)CN108440397; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem