In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33252-30-1, name is 2-Chloroisonicotinonitrile, the common compound, a new synthetic route is introduced below. Quality Control of 2-Chloroisonicotinonitrile
General procedure: Aromatic or aliphatic nitriles (2 mmol) were dissolved in 5 ml of [bmim]HSO4 and the reaction mixture was heated at 60-65 C for 1-3 h. The progress of reaction was monitored by TLC. After completion of reaction, as checked by TLC, the reaction mixture was poured into water containing crushed ice. The product was precipitated out, filtered and dried. The yield of the final product was high (>90%) in all cases. All final products obtained were found sufficiently pure so it didn?t need further purification.The filtrate was concentrated under vacuum, washed with diethylether twice and concentrated under high vacuum. After proper drying under reduced pressure, approximately 95% ionic liquid was recovered from the reaction and compared with the original ionic liquid to check its authenticity. The efficiency of recovered ionic liquid in conversion of nitriles to acids was found unchanged in comparison to the original one and we reused it up to 5-6 cycles without any significant loss of its activity.
The synthetic route of 33252-30-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kumar, Satyanand; Dixit, Sandeep Kumar; Awasthi, Satish Kumar; Tetrahedron Letters; vol. 55; 28; (2014); p. 3802 – 3804;,
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