Electric Literature of 824429-51-8, Adding some certain compound to certain chemical reactions, such as: 824429-51-8, name is tert-Butyl (2-(hydroxymethyl)pyridin-3-yl)carbamate,molecular formula is C11H16N2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 824429-51-8.
N- [2- (hydroxymethyl) pyridin-3-yl] carbamic acid tert-butyl ester(0.15 g) in dichloromethane (1 mL)Thionyl chloride (0.096 g) was added, and the mixture was stirred at room temperature for 1 hour.The reaction mixture was poured into saturated aqueous sodium hydrogen carbonate solution and the crude product was extracted with dichloromethane. The organic layer was washed with saturated saline and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane)To give N- [2- (chloromethyl) pyridin-3-yl] carbamic acid tert-butyl ester (0.12 g).A mixture of the product (0.12 g), dichloromethane (2 mL), potassium cyanide (0.039 g), tetrabutylammonium hydrogen sulfate (0.017 g) and water (0.5 mL) was stirred at room temperature for 3 hours. Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, and the crude product was extracted with ethyl acetate. The organic layer was washed with saturated saline and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane)To give N- [2- (cyanomethyl) pyridin-3-yl] carbamic acid tert-butyl ester.Concentrated hydrochloric acid (0.072 g) and 10% palladium on carbon (50% wet, 0.03 g) were added to the product methanol (3 mL) – dichloromethane (3 mL) mixture, and the mixture was stirred at room temperature under a hydrogen atmosphere (0.32 MPa) Followed by stirring. The reaction mixture was passed through a celite pad and the filtrate was concentrated under reduced pressure. The residue was purified by aminopropyl silica gel column chromatography (eluent: ethyl acetate / methanol) to give the title compound (0.011 g). Structural formula, spectral data and purification conditions are shown in Table 26.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 824429-51-8, tert-Butyl (2-(hydroxymethyl)pyridin-3-yl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; Hirasawa, Hideaki; Tanada, Fumiya; Mutai, Yousuke; Fushimi, Nobuhiko; Kobayashi, Junichi; Kijima, Yoshiro; (267 pag.)JP2018/108988; (2018); A;,
Pyridine – Wikipedia,
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