Application of 13143-47-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13143-47-0, name is 1-(4-Aminophenyl)-1H-pyridin-2-one, molecular formula is C11H10N2O, molecular weight is 186.21, as common compound, the synthetic route is as follows.
General procedure: To a stirred solution of 1-(4-aminophenyl)pyridin-2(1H)-one (3a) (0.90 g, 4.8 mmol), K2CO3 (0.80 g, 5.8 mmol) and DMAP (0.05 g, 0.4 mmol) inTHF (20 mL), solution of 2-nitrobenzoyl chloride (2a) (1.15 g, 6.24 mmol) in THF (5 mL) was addedat room temperature and the mixture was refluxed for 2 h. The reaction mixture was cooled downto room temperature and concentrated under reduced pressure. Then water (100 mL) was addedto the mixture and stirred for 10 min at room temperature. The resulting precipitate was collectedby filtration. The reaction was monitored by TLC with EA.
The chemical industry reduces the impact on the environment during synthesis 13143-47-0, I believe this compound will play a more active role in future production and life.
Reference:
Article; Wang, Wenzhi; Yuan, Jing; Fu, Xiaoli; Meng, Fancui; Zhang, Shijun; Xu, Weiren; Xu, Yongnan; Huang, Changjiang; Molecules; vol. 21; 4; (2016);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem