Synthetic Route of 55676-21-6, Adding some certain compound to certain chemical reactions, such as: 55676-21-6, name is 1-(2-Chloropyridin-3-yl)ethanone,molecular formula is C7H6ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55676-21-6.
General procedure: 2-chloride pyridine derivatives (5mmol, 1.0eq), K2CO3 (7.5mmol, 1.5eq), 3-amino-1H-pyrazole-4-carbonitrile (5mmol, 1.0eq), CuI (0.5mmol, 0.1eq), ethylenediamine (1.0mmol, 0.2eq) were suspended in DMF. After three cycles of evacuating and backfilling with argon, the reaction tube was sealed and heated to 110°C for 20 hours. After cooling to room temperature, the mixture was diluted with water (100mL), and extracted with ethyl acetate (100mL×3). The organic phase was washed with water, brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified using silica gel chromatography to give the title compounds, yield 37-45percent.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55676-21-6, 1-(2-Chloropyridin-3-yl)ethanone, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Fang, Zhen; Wang, Tian-qi; Li, Hui; Zhang, Guo; Wu, Xiao-ai; Yang, Li; Peng, Yu-lan; Zou, Jun; Li, Lin-li; Xiang, Rong; Yang, Sheng-yong; Bioorganic and Medicinal Chemistry Letters; vol. 27; 14; (2017); p. 3201 – 3204;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem