Reference of 5223-06-3 ,Some common heterocyclic compound, 5223-06-3, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 100 g (0.655 mol) [2- (5-ETHYL-PYRIDIN-2-YL)-ETHANOL] in 500 mL acetic acid was added 118 g (1.049 mol) 30% hydrogen peroxide at 25-30 [C.] Reaction mixture was refluxed at 100 [C] [(TLC)] for 14 hr. After completion of the reaction acetic acid was removed under vacuum, and the residual mass was poured in excess water and made alkaline by 10% [NA2C03] solution. Product was extracted with ethyl acetate and after concentrating ethyl acetate [IN VACUO, 89. 58 G (81%)] crystalline product was obtained. The product obtained was characterized by Mass, [13C] NMR, [AND’H] NMR, which are as given below. Mass spectrum (m/z) : 168. 1 (M + [H) +] [3C-NMR] [(CDC13)] [: 6] 170.7, 148.2, 138.7, 135.9, 125. 8,62. 0,34. 2,25. 5, 14.4 ‘H-NMR [(CDC13)] : [S] 7.07-8. 14 (3H, m), 5.7 [(1H,] broad s), 3.9 (2H, t), 3.2 (2H, t), 2.6 (2H, q), 1.2 (3 H, t)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5223-06-3, its application will become more common.
Reference:
Patent; CADILA HEALTHCARE LIMITED; WO2004/7490; (2004); A2;,
Pyridine – Wikipedia,
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