With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1796-83-4, name is Dimethyl pyridine-3,4-dicarboxylate, molecular formula is C9H9NO4, molecular weight is 195.1721, as common compound, the synthetic route is as follows.name: Dimethyl pyridine-3,4-dicarboxylate
10267] Compound WXO1S-2 (26.00 g, 133.22 mmol, 1.00 eq) was dissolved in anhydrous dichioromethane (400.00 mE), then 3-chloroperoxybenzoic acid (40.57 g, 199.83 mmol, 85% purity, 1.50 eq) was added to reaction liquid at 0 C., and the mixture was stirred at 00 C. for 14 h under nitrogen condition. After reaction, water (500 mE) and sodium thiosulfate (about 20 g) were added in reaction liquid to quench the reaction. The resulting mixture was stirred for 1 h, and neutralized with sodium bicarbonate powder (about 20 g), then extracted with dichioromethane (400 mEx3). The organic phase was washed with saturated sodium chloride solution (400 mEx3), dried with anhydrous sodium sulfate and filtered. The filtrate was dried by rotary evaporation to obtain the crude. The crude was purified by colunm chromatography (petroleum ether:ethyl acetate=50:1-1:1) to obtain WXO18-3. ?H NMR (400 MHz, CDC13) oe ppm: 8.35 (d, J=1.64 Hz, 1H), 8.25 (dd, J=6.78, 1.76 Hz, 1H), 7.70 (d, J=6.78 Hz, 1H), 3.96 (s, 3H), 3.93 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1796-83-4, Dimethyl pyridine-3,4-dicarboxylate, and friends who are interested can also refer to it.
Reference:
Patent; SHENZHEN SALUBRIS PHARM CO LTD.; Wu, Chengde; Yan, Jie; Xu, Wenjie; Yu, Tao; Li, Ning; Chen, Shuhui; US2018/305346; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem