Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 73583-37-6, name is 4-Bromo-2-chloropyridine. A new synthetic method of this compound is introduced below., SDS of cas: 73583-37-6
The compound obtained in Step 1 670 mg (2.03 mmol) to 10 ml of 1,4-dioxane was dissolved in then PdCl2 (dppf) 2.CH2Cl2 163 mg (0.20 mmol) and 4-bromo-2-chloropyridine 1.16 g (6.09 mmol), 2M- sodium carbonate (Na2CO3) aqueous solution was added to 3.05 ml (6.09 mmol) was stirred under reflux at 110 for 4 hours. Celite (celite), filtered and concentrated under reduced pressure the filtrate was purified by silica gel column chromatography (dichloromethane: methanol = 3: 1, v / v) 380 to yield a target compound as a yellow solid in a yield of 60% mg (1.20 gained mmol)
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Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; LEE, KYU YANG; IM, JAE CHO; LEE, BYUNG HO; OH, KWANG SEOK; KIM, JEONG YEONG; OH, SEUNG AE; LEE, JEONG HYUN; (38 pag.)KR2015/117319; (2015); A;,
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