Synthetic Route of 130721-78-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 130721-78-7, name is tert-Butyl (4-chloropyridin-2-yl)carbamate. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a – 78Csolution of N-Boc-2-amino-4-chloropyridine(3.6g, 15.8 mmol) and TMEDA (3.7 g, 31.2 mmol) in anhydrous THF (67 mL) wasadded dropwise a 1.3 M solution of n-BuLiin hexane (25 mL, 31.2 mmol). The reaction mixture was stirred at -78C during 1hand then a solution of I2 (8.0 g, 31.2 mmol) inTHF (27 mL) was added dropwise. Temperature was allowed to rise at roomtemperature during 1h and the reaction mixure was hydrolized with a saturatedsolution of ammonium chloride (30 mL) and extracted with EtOAc (3 x 30 mL). Thecombined organic phases were washed with a 10% solution of Na2S2O3(30 mL), brine (30 mL), dried over MgSO4, filtered and concentrated under reduced pressure. The iodinated aminopyridine was obtained as a beigesolid (4.2 g, 76%) without further purification.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130721-78-7, tert-Butyl (4-chloropyridin-2-yl)carbamate.
Reference:
Article; Silpa, Laurence; Niepceron, Alisson; Laurent, Fabrice; Brossier, Fabien; Penichon, Melanie; Enguehard-Gueiffier, Cecile; Abarbri, Mohamed; Silvestre, Anne; Petrignet, Julien; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 114 – 120;,
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