Reference of 10366-35-5 ,Some common heterocyclic compound, 10366-35-5, molecular formula is C6H5ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 3 2-[4-(2,3-Dihydroxypropyl)piperazin-1-yl]nicotinamide Operation was carried out in a manner similar to the one described in Example 2, using 1.6 g of 2-chloronicotinamide, 3.2 g of 1-(2,3-dihydroxypropyl)piperazine and 30 ml ethanol and refluxing overnight. Column purification of the residue gave 1 g of 2-[4-(2,3-dihydroxypropyl)piperazin-1-yl]nicotinamide, which, recrystallized from acetone, melted at 140-142C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10366-35-5, 2-Chloronicotinamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DOMPE’ FARMACEUTICI S.p.A.; EP230402; (1993); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem