Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1227577-03-8, name is 2-Chloro-3-fluoropyridin-4-amine. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H4ClFN2
To a solution of 2-(6-(difluoromethyl)pyridin-2-yl)-4-phenoxypyrrolo[2, 1- f][1,2,4]triazine (100 mg, 0.296 mmol) and 2-chloro-3-fluoropyridin-4-amine (65.0 mg, 0.443 mmol) in DMF (2 mL) was added NaH (25.8 mg, 0.59 1 mmol) at 0 C and the reaction mixture was warmed to room temperature and stirred for 2 h. The reaction mixture was poured in to 10 mL ice/H20. The resulting suspension was filtered. The isolated solid was used in the next reaction without further purification. LCMS m/z 391.1 (M+H); rt 1.29 mm; Conditions I.
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Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HARIKRISHNAN, Lalgudi S.; FINK, Brian E.; BORZILLERI, Robert M.; TONUKUNURU, Gopikishan; RAHAMAN, Hasibur; WARRIER, Jayakumar Sankara; SESHADRI, Balaji; (411 pag.)WO2017/15425; (2017); A1;,
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