Electric Literature of 148493-37-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 148493-37-2, name is 2,6-Dichloro-3-iodopyridine, molecular formula is C5H2Cl2IN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a 1 necked round bottom flask, with stirrer, and air condenser, under nitrogen, is added 2,6-dichloro-3-iodo-pyridine (1.0 g, 3.8 mmol), 2- [(E)-2-ethoxyvinyl]-4,4,5,5-tetramethyl-l,3,2-dioxaborolane (0.9 g, 4.8 mmol), CS2CO3 (3.75 g, 11.5 mmol), l,4-dioxane (19.2 mL), and water (4.26 mL). This reaction mixture is purged 3 times alternating between vacuum and nitrogen, and [l,T bis(diphenylphosphino) ferrocene]dichloropalladium(II) (0.2 g) is added. The resulting mixture is stirred for 3 hr at 90 C, the reaction is poured onto saturated aqueous NH4Cl, and the aqueous mixture is extracted three times with EtOAc. The combined organic extracts are dried over MgS04, filtered, and the filtrate is concentrated under reduced pressure. The resulting residue is purified by flash chromatography over silica gel, eluting with a gradient of 0-100% EtOAc in cyclohexane, to afford the title compound (748 mg, 89% yield), after solvent evaporation of the desired chromatographic fractions. NMR (300 MHz, CDCh): d 1.37 (m, 3H), 3.97 (m, 2H), 5.97 (m, 1H), 6.99 (m, 1H), 7.16 (m, lH),7.60 (m, 1H).
According to the analysis of related databases, 148493-37-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ELI LILLY AND COMPANY; DREYFUS, Nicolas Jacques Francois; FALLER, Andrew; (44 pag.)WO2019/245907; (2019); A1;,
Pyridine – Wikipedia,
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