Adding a certain compound to certain chemical reactions, such as: 884495-39-0, 5-Bromo-2-methoxypyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H7BrN2O, blongs to pyridine-derivatives compound. HPLC of Formula: C6H7BrN2O
A mixture of 2,4-difluorobenzenesulfonyl chloride (12.76 g, 60 mmol), pyridine (6 mL, 75 mmol), 5-bromo-2-methoxypyridin-3-amine 15a (10.15 g, 50 mmol), and DMAP (1.22 g, 10 mmol) in DCM (200 mL) was stirred at rt overnight. Water was added and the resulting mixture was extracted with DCM (200 mL×3). The combined organic layers were washed with water (200 mL×2) and brine (30 mL×2), dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography (silica gel, PE/EtOAc = 5:1) to afford 16a as a yellow solid (16.48 g, 87% yield). 1H NMR (400 MHz, DMSO-d6) delta 10.46 (s, 1H), 8.13 (d, J = 2.3 Hz, 1H), 7.84 – 7.70 (m, 2H), 7.64 – 7.51 (m, 1H), 7.23 (td, J = 8.5, 2.0 Hz, 1H), 3.61 (s, 3H). MS (ESI+) m/z 379.1 [M + H]+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,884495-39-0, 5-Bromo-2-methoxypyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Article; Lin, Songwen; Wang, Chunyang; Ji, Ming; Wu, Deyu; Lv, Yuanhao; Sheng, Li; Han, Fangbin; Dong, Yi; Zhang, Kehui; Yang, Yakun; Li, Yan; Chen, Xiaoguang; Xu, Heng; Bioorganic and Medicinal Chemistry; vol. 26; 3; (2018); p. 637 – 646;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem