Application of 131747-63-2 ,Some common heterocyclic compound, 131747-63-2, molecular formula is C6H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A solution of 4-bromopyridine-2-carboxaldehyde (10 g), trimethyl orthoformate (23.3 mL) and PTSA (1.51 g) in Me OH (261 mL) was stirred at reflux for 1 day. Sat. aq. NaHC03 and EA were added, the layers were separated and the aq. layer was twice extracted with EA, dried over MgSOzt, filtered and concentrated under reduced pressure. The crude product was purified by filtration over 200 mL silicagel using Hept/EA 1/1 as solvent. The title compound was obtained as a colourless liquid (11.5 g; 95% yield). MS I (ESI, m/z): 231.99 [M+H+]; tR = 0.63 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,131747-63-2, its application will become more common.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; CREN, Sylvaine; RUEEDI, Georg; ZUMBRUNN, Cornelia; (60 pag.)WO2017/179002; (2017); A1;,
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