Adding a certain compound to certain chemical reactions, such as: 14150-94-8, 1-Methyl-3,5-dinitro-1H-pyridin-2-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H5N3O5, blongs to pyridine-derivatives compound. HPLC of Formula: C6H5N3O5
11.2 (3-Nitro-5,6,7,8-tetrahydro-quinolin-5 and 7-yl)-carbamic acid benzyl ester; A mixture of 1-methyl-3,5-dinitro-2-pyridone (3.66 g, 18.38 mmol) and (3-oxo- cyclohexyl)-carbamic acid benzyl ester (4.55 g, 18.39 mmol) in methanolic am¬ monia (1 M1 140 ml) was heated at 65C for 1.5 h. It was then concentrated and digested in CH2CI2. The organic layer was washed with H2O (x2), dried (Na2SO4) and evaporated. The residue was chromatographed on silica gel (heptane:ethyl acetate, 3:1) to afford a mixture 1/2 of the 5 and 7 regioisomers (4.51 g, 75% for two steps) as a pale yellow gum. MS (ESI+) m/z = 328.1 [M+H]+ 1H NMR (400 MHz, CDCI3) : delta (ppm) 1.83 (m, 1.5H), 2.01 (m, 1H), 2.20 (m, 1.5H), 2.90 (dd, J = 18.1 , 8.7 Hz1 1H), 3.00 (t, J = 6.4 Hz1 2H), 3.05 (t, J = 6.4 Hz, 1 H)13.43 (dd, J = 18.1 , 5.2 Hz1 1H)1 4.16 (m, 1H)1 4.81 (bs, 1 H)1 5.03 (bs, 1H), 5.12 (s, 2H), 5.19 (s, 1 H), 7.36 (m, 7.5 H)1 8.19 (bs, 1H), 8.46 (bs, 0.5H)1 9.20 (d, J = 1.9 Hz, 1 H), 9.23 (d, J = 2.1 Hz1 0.5H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,14150-94-8, 1-Methyl-3,5-dinitro-1H-pyridin-2-one, and friends who are interested can also refer to it.
Reference:
Patent; ABBOTT GMBH & CO.KG; WO2006/40178; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem