Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1570-48-5, name is 1-(Pyridin-3-yl)propan-1-one. A new synthetic method of this compound is introduced below., Safety of 1-(Pyridin-3-yl)propan-1-one
A solution of the 3-propionylpyridine (5g, 37 mmol) , (S)-(-)-2-methylpropane-2- sulfinamide (4.7 g, 38.8 mmol) and titanium (IV) ethoxide (17.8g, 78 mmol) in THF (100 mL) was heated at 80C for 3 days. After cooling, brine (100 mL) and EA (100 mL) were added. The mixture was stirred at RT for 1 h. The mxture was filtered through Celite, and the pad was washed with EA. The organic phase was seperated, concentrated, and the residue was chromatographed (eluted with 2:1 hexane:EA) to give the product as a colorless oil (8.15g, 92%).
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Reference:
Patent; EXITHERA PHARMACEUTICALS, INC.; CHENARD, Bertrand, L.; XU, Yuelian; STASSEN, Frans, L.; HAYWARD, Neil, J.; (225 pag.)WO2018/118705; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem