Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents was written by Shakya, Bhushan;Yadav, Paras Nath;Ueda, Jun-ya;Awale, Suresh. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Recommanded Product: 4-Methylpicolinonitrile This article mentions the following:
Series of 2-pyridineformamide thiosemicarbazones I [R1R2 = pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, etc.; R3 = H, 4-Me] were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Recommanded Product: 4-Methylpicolinonitrile).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 4-Methylpicolinonitrile