Dimerization of 2-pyridylisonitriles produces π-extended fused heteroarenes useful as highly selective colorimetric and optical probes for copper ion was written by Shao, Na;Pang, Guang-Xian;Wang, Xiao-Rong;Wu, Rui-Juan;Cheng, Ying. And the article was included in Tetrahedron in 2010.Synthetic Route of C7H6N2 This article mentions the following:
A very simple synthesis of pyrido[2”,1”:2′,3′]imidazo[4′,5′:4,5]imidazo[1,2-a]pyridines (I) was achieved from the dimerization of 2-pyridylisonitriles. The optical responses of these π-extended fused heteroarenes to metal ions were studied by UV-visible absorption spectrum in acetonitrile. Most of compounds I selectively responded to Cu2+, and the limit of detection was ∼3.5 × 10-7 M when using the best probe, 3,9-dimethylpyrido[2”,1”:2′,3′]imidazo[4′,5′:4,5]imidazo[1,2-a]pyridine (I, X = 4-Me). Meanwhile some compounds I specifically showed a color change from colorless to red or yellow when they are exposed to copper ion in acetonitrile, whereas other transition, alkali and alk. earth metal ions could not induce a color change. This work not only established a direct access to π-extended fused heteroarenes, but also supplied novel sensitive and selective colorimetric and optical probes for copper ion. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Synthetic Route of C7H6N2).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Synthetic Route of C7H6N2