Adding a certain compound to certain chemical reactions, such as: 94170-15-7, 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, blongs to pyridine-derivatives compound. Quality Control of 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde
Intermediate 1-10 (134.73 mg, 0.39 mmol) was dissolved in DCM (6 mL)4-Aldehyde-1-methylpyridine-2(1H)-one (64.2 mg, 0.468 mmol) and NaBH(OAc)3 (206.6 mg, 0.975 mmol),Stir at room temperatureThe reaction is complete,Add saturated aqueous sodium bicarbonate (5 mL),Extracted with DCM (3 x 10 mL),Combine the organic phase,Wash with water (2 × 5mL),Dry over anhydrous sodium sulfate,Filtered, concentrated,The crude product was purified by preparative HPLC to give a white solid(10.0 mg, yield: 5.5%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,94170-15-7, 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Wang Lin; Yang Xiaoju; Tian Yuwei; (46 pag.)CN108341819; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem