Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1003-68-5, name is 5-Methylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows. 1003-68-5
1 (10.9 g, 0.1 mol) and 2 (31.6 g, 0.12 mol) were dissolved in dry DMF (200 mL) under N2 atmosphere, then anhydrous K2CO3 (27.6 g, 0.2 mol) and CuI (3.8 g, 0.02 mol) were added. The reaction mixture was refluxed for 10 h. After cooling, the mixture was quenched with saturated NaHCO3 (aq, 150 mL), and extracted with EtOAc (3¡Á50 mL), the organic layers were collected, dried over anhydrous Na2SO4, filtered and concentrated, crystallized from EtOAc /PE. The desired product 3 was obtained as a yellowish solid (21.5 g, 74%), mp: 123-124. 1HNMR (400MHz, CDCl3): delta 7.05-7.46 (m, 11H), 6.62 (d, J=9.2 Hz, 1H), 5.11 (s, 2H), 2.10 (s, 3H).
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Reference:
Article; Ma, Zhen; Pan, Youlu; Huang, Wenhai; Yang, Yewei; Wang, Zunyuan; Li, Qin; Zhao, Yin; Zhang, Xinyue; Shen, Zhengrong; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 220 – 223;,
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