Reference of 107867-51-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 107867-51-6 as follows.
General procedure: A mixture of 2,3-diaminopyridine in diethyl oxalate (10 mL/1 mmol phenyldiamine) was heated to reflux for 4 h before cooled to room temperature. The resulted solid was filtered,washed with ethyl acetate and 95% ethanol, decolorized with activated charcoal and recrystallized in water and DMF or DMSO to give 5-azaquinoxalinediones as white solid. 5.2.2.6 7-Trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione (6) The title compound was prepared from 2-amino-5-trifluoromethylpyridine according to the general procedure as white solid (635 mg, 27.5%). IR (KBr) nu 3055, 1717, 1698, 1627, 1342, 1165, 1094 cm-1; 1H NMR (400 MHz, DMSO-d6) delta 7.63 (1H, d, J = 2.0 Hz, H-8), 8.44 (1H, s, H-6), 12.13 (1H, s, NH-1), 12.71 (1H, s, NH-4); 13C NMR (100 MHz, DMSO-d6) delta 118.74 (t), 120.04 (d), 122.52, 124.18 (d), 138.99 (t), 142.95, 154.95, 156.39; HRMS-EI C8H4F3N3O2 calcd [M+Na]+ 254.0153, found 254.0150.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,107867-51-6, its application will become more common.
Reference:
Article; Xie, Dongsheng; Lu, Jun; Xie, Jin; Cui, Junjun; Li, Teng-Fei; Wang, Yan-Chao; Chen, Yuan; Gong, Nian; Li, Xin-Yan; Fu, Lei; Wang, Yong-Xiang; European Journal of Medicinal Chemistry; vol. 117; (2016); p. 19 – 32;,
Pyridine – Wikipedia,
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