In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide, the common compound, a new synthetic route is introduced below. Formula: C7H4F6N2O4S2
To a solution of the obtained compound (34 mg, 0.08 mmol) in CH2Cl2 (0.8 mL) were added pyridine (15 mg, 0.19 mmol), 2-[N,N-bis(trifluoromethane-sulfonyl) amino]pyridine (34 mg, 0.096 mmol), and DMAP (1 mg) at 0 C. The reaction mixture was stirred at rt for 30 min, and the reaction was stopped by addition of water. The mixture was extracted with CH2Cl2 and the organic layer was washed with water and dried over anhydrous MgSO4. The solvent was concentrated, and the obtained residue was purified by PTLC (AcOEt/hexane = 1:4) to obtain the title compound (37 mg, 83%). 1H NMR (CDCl3) delta: 1.11-1.24 (1H, m), 1.42 (6H, s), 1.43 (3H, s), 1.53 (3H, s), 1.74 (1H, dt, J = 13.7, 3.9 Hz), 1.80-1.93 (1H, m), 2.96 (1H, dt, J = 11.1, 3.6 Hz), 3.59-3.92 (5H, m), 3.98 (2H, s), 7.00-7.03 (2H, m), 7.10-7.35 (6H, m).
The synthetic route of 145100-50-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ohtake, Yoshihito; Sato, Tsutomu; Matsuoka, Hiroharu; Kobayashi, Takamitsu; Nishimoto, Masahiro; Taka, Naoki; Takano, Koji; Yamamoto, Keisuke; Ohmori, Masayuki; Higuchi, Takashi; Murakata, Masatoshi; Morikawa, Kazumi; Shimma, Nobuo; Suzuki, Masayuki; Hagita, Hitoshi; Ozawa, Kazuharu; Yamaguchi, Koji; Kato, Motohiro; Ikeda, Sachiya; Bioorganic and Medicinal Chemistry; vol. 20; 13; (2012); p. 4117 – 4127;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem