Application of 113293-70-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 113293-70-2 as follows.
2,6-dichloroisonicotinaldehyde (25.3 g, 144 mmol) in toluene (205 mL)as well asethylene glycolTo a solution in (12.06 mL, 216 mmol),p-Toluenesulfonic acid monohydrate (0.54 g, 2.87 mmol) was added in one portion.The reaction was heated to reflux using a Dean-Stark trap apparatus for 16 hours.Cool the reaction to room temperature,Add 200 mL of ethyl acetate,Quenched by addition of aqueous NaHCO3. Separate the layers,The aqueous phase was extracted with ethyl acetate (2 × 20 mL). The combined organic extracts are then washed once more with NaHCO3,Dried over MgSO4, filtered and concentrated.The product was purified by silica gel chromatography eluting with 5-40% ethyl acetate: heptane,The product (24.8 g, 78% yield) was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,113293-70-2, its application will become more common.
Reference:
Patent; Abbvie Incorporated; Argiriadi, Maria A.; Breinlinger, Eric C.; Chien, Ellen Yulin Tsai; Cowart, Marlon D.; Frank, Kristine E.; Friedman, Michael M.; Hardy, David J.; Herold, J. Martin; Liu, Huaqing; Chu, Wei; Scanio, Marc J.; Schrimpf, Michael R.; Vargo, Thomas R.; Van Epps, Stacy A.; Webster, Matthew P.; Little, Andrew J.; Dunstan, Teresa A.; Katcher, Matthew H.; Schedler, David A.; (232 pag.)JP6557436; (2019); B1;,
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