Adding a certain compound to certain chemical reactions, such as: 118289-17-1, 2-Bromopyridine-4-carboxaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H4BrNO, blongs to pyridine-derivatives compound. COA of Formula: C6H4BrNO
(a) 2-bromo-4-(difluoromethyl)pyridine To a solution of 2-bromoisonicotinaldehyde (2 g, 10.752 mmol) in dichloromethane was added DAST (6.613 g, 32.257 mmol) at -78 C. The mixture was warmed to room temperature slowly in 2 hours. The reaction mixture was quenched with saturated sodium bicarbonate and extracted with dichloromethane. The combined organic layer was washed with brine, dried over anhydrous sodium sulfate and evaporated to give 2-bromo-4-(difluoromethyl)pyridine (2 g, yield 90%). 1HNMR (400 MHz, CDCl3): delta=8.52?8.51 (d, J=8.0 Hz, 1H), 7.63 (s, 1H), 7.40?7.38 (d, J=8.0 Hz, 1H), MS (ESI): M/Z (M+1)=207.95.
The synthetic route of 118289-17-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KIM, RONALD M.; Liu, Jian; Gao, Xiaolei; Boga, Sobhana Babu; Guiadeen, Deodialsingh; Kozlowski, Joseph A.; Yu, Wensheng; Anand, Rajan; Yu, Younong; Selyutin, Oleg B.; Gao, Ying-Duo; Wu, Hao; Liu, Shilan; Yang, Chundao; Wang, Hongjian; US2014/206681; (2014); A1;,
Pyridine – Wikipedia,
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