Reference of 13472-85-0 ,Some common heterocyclic compound, 13472-85-0, molecular formula is C6H6BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of diispropylamine (63 g, 642 mmol) in anhydrous THF (500 ml) was added n-BuLi5 (2.5 M, in hexane, 256 mL, 642 mmol) dropwise under a N2 atmosphere at -78 C, and themixture was stirred for 30 min. To the reaction mixture was added a solution of 5-bromo-2-methoxypyridine (100 g, 535 mmol) in 100 mL ofTHF. The reaction mixture was stirred at-78 oc for 1h, and then DMF (50 ml, 642 mmol) was added. After stirring for 30 min, the reactionmixture was quenched with water and extracted with EtOAc. The organic layer was washed with10 water and brine, and dried over Na2S04. After filtration and concentration, the residue waspurified by silica gel column chromatography (eluted with petroleum ether: ethyl acetate= 10: 1) togive solid 39-1. MS(ESI) m/e (M+H+): 216.0/218.0.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13472-85-0, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; HAGMANN, William K.; NARGUND, Ravi P.; BLIZZARD, Timothy A.; JOSIEN, Hubert; BIJU, Purakkattle; PLUMMER, Christopher W.; DANG, Qun; LI, Bing; LIN, Linus S.; CUI, Mingxiang; HU, Bin; HAO, Jinlai; CHEN, Zhengxia; WO2014/19186; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem